The Cyprus Protocol – Multimodal Combination Therapy for Long COVID, Post-Vac and Chronic Illnesses

In the field of HIV and cancer, combination therapy is one of the most successful forms of treatment – often it is the gold standard in the specific field. 

Gemeinsam mit Mitwirkenden aus der ganzen Welt und durch unsere klinische Erfahrung in Verbindung mit patientengeleiteter Forschung haben wir das erste multimodale Kombinationstherapieprotokoll für lange COVID, Post-Vac-Syndrom und chronische Krankheiten entwickelt.

 We named it after it’s place of origin: 

Das Zypern-Protokoll".

Below you find a dynamic list of the protocol’s elements and a treatment schedule example.

Bedingungen, die wir behandeln

Welche Krankheiten behandeln wir im Apheresezentrum mit dem Zypern-Protokoll?

Im Folgenden finden Sie einige Beispiele (ohne Anspruch auf Vollständigkeit) für die häufigsten Erkrankungen, die wir in unserer Klinik behandeln:

  • Langer Covid (PCS)
  • Post-Vac (PVS)
  • Postinfektiöse/postvirale Syndrome
  • POTS
  • EDS
  • MCAS / IBS / SIBO
  • PANS / PANDAS
  • PIMS / MIS-C
  • Autoimmunkrankheiten
  • Chronisches Müdigkeitssyndrom
  • Reaktivierte Erkrankungen (EBV, Mono, CMV, Herpes, Babesien, Bartonellen)
  • Lyme-Krankheit
  • Fibromyalgie
  • ME/CFS
  • Multiple Sklerose
  • Lupus
  • Rheumatoide Arthritis
  • Sjögrens-Syndrom
  • Raynaud’s Disease
  • Sklerodermie
  • Alzheimer
  • Parkinson
  • SFN / Neuropathie
  • MCS
  • Andere Erkrankungen mit Entzündungs-, Autoimmun- und Mikrozirkulationsproblemen sowie Erkrankungen mit Toxinen oder Krankheitserregern als Ursache 

Die Elemente des Zypern-Protokolls

Klicken Sie auf die einzelnen Elemente des Zypern-Protokolls, um weitere Einzelheiten zu erfahren

Für jeden Patienten muss das Protokoll individuell angepasst werden.

With the new diagnostic tools of our D-T-R model – Continous Diagnostics we are now able to apply targeted treatments with higher precision. 

Klinischen Ernährungs Supervision

Independent of the treatment a patient is undergoing – without adapted nutrition for the three treatment phases pre-treatment, on-treatment and post-treatment, the achievable results differ.
This is why we base our Combination Therapy on individual and personalized nutrition plans for every patient, based on the results of blood panel test and food intolerance test that show IgG reactions to 287 foods (vegetables, fish & seafood, fruits, spices, nuts, legumes, meat, egg & milk, cereals & seeds, nuts, coffee & tea and novel foods). 
Our Clinical Nutritionist Chryso Zorbas will hold your hand nutritionally from day one and guide you along the therapy with a personalized diet plan that will enhance your recovery process. Needless to say that our Health Coaching (see below) is a perfect match and goes hand in hand with our Clinical Nutrition Supervision.
Learn more about Clinical Nutrition Supervision here

Gesundheits Coaching

Chronic Illness is very complex – having an expert patient turned professional Health Coach by your side throughout your whole journey offers priceless knowlege and guidance.
Our Health Coach Tanja Walser will coach you from day one and guide you along the therapy with a personalized coaching plan that will include all the dos and don’ts and give you a headstart despite brainfog, anxiety or other symptoms you are battling with.
Learn more about Health Coaching here

H.E.L.P. Apherese, Inuspherese® und Immunadsorption

Our most effective treatments to date: At the core of our multimodal Combination Therapy are several forms of Therapeutic Apheresis’ – special blood purifications by precipitation/adsorption/filtration procedures. They serve to treat microcirculation / blood flow issues (microclots are removed, blood flow increased) and removes pathogenic or disease-sustaining proteins as well as protein-bound substances and autoantibodies from the blood. Amongst other substances environmental toxins, inflammation proteins, viral spike protein, cholesterol + autoantibodies are removed

Learn more about H.E.L.P. Apheresis 
Learn more about Inuspheresis®  
Learn more about Immunoadsorption 
In some cases H.E.L.P. Apheresis will be combined with TPPE – Therapeutic Partial Plasma Exchange 

Ganzkörper-Hyperthermie

Das Ganzkörper-Hyperthermie-System Heckel HT3000 ermöglicht eine gezielte Erhöhung der Körperkerntemperatur, die von leichtem bis hohem Fieber reicht. Die Ganzkörperhyperthermie behandelt nicht nur die Symptome, sondern zielt auch darauf ab, eine verbesserte Regulationskontrolle im gesamten Organismus wiederherzustellen. Die Heckel Ganzkörper-Hyperthermie-Systeme sind ein sinnvoller Beitrag zur Behandlung einer Vielzahl von Erkrankungen und Beschwerden – von der Gesundheitsförderung über die Schmerzlinderung bis hin zur unterstützenden Behandlung von chronischen Erkrankungen und Krebserkrankungen. Bei Long Covid und Post Vac sind die Befreiung von Rezeptoren und das Aufbrechen von pathogenen Proteinen weitere erwünschte Effekte.

IV Therapy – Intravenous Treatments (including Peptides and Chelation Agents)

Long Covid and many other Chronic Illnesses are at their root an endothelitis/vasculitis with severe inflammation, combined with hypercoagulation and often viral persistence. Autoimmunity components can be involved too. 
IV treatments work directly where needed the most: in the blood vessels in the desired concentration.

IV/Intravenous therapies that are used in our Long COVID and Chronic Illnesses Combination Therapy are:

– IV Vitamin C (Reducing inflammation)
– IV Glutathione (Antioxidant)
– IV Multivitamin Protocol (Balancing deficiencies)
– IV NAD+ (Metabolism/mitochondria benefits)
– IV Alpha Lipoic Acid (Metabolism/nerve pain reduction)
– IV Zinc (Reducing inflammation, speeding up recovery)
– IV Magnesium (Electrolyte reducing fatigue and anxiety)
– IV NAC (Reduces brainfog/relieves respiratory discomfort)
– IV Taurin (Is Cytoprotective (cell protective) and detoxyfying)
– IV Arginine (Increases elasticity of blood vessels and increases blood flow)
– IV Lysine (Increases cell healing and wound healing)
– Other IVs: Iron, Selenium, Amino Acids, Minerals and more

Peptide Therapy:

Peptide therapy offers a groundbreaking approach to restoring  balance and vitality for individuals struggling with long COVID,  post-vaccine syndrome, and chronic illnesses. Peptides are short chains  of amino acids that act as signaling molecules in the body, promoting  tissue repair, immune modulation, and cellular rejuvenation. By  targeting underlying dysfunctions such as inflammation, impaired  immunity, and mitochondrial damage, peptide therapy can accelerate  recovery, enhance energy, and support overall wellness. Tailored to each  patient’s unique needs, this therapy provides a safe and effective way  to improve quality of life, fostering the body’s natural ability to heal  and thrive.  

Find more information on our IV Therapy and Peptide Therapy click here for iv therapy and peptide therapy

Chelation Therapy:

Chelation therapy is a medical intervention characterized by the administration of chelating agents, substances with a high affinity for certain metal ions, to facilitate the removal of heavy metals and minerals from the body. 

Find more information on Chelation Therapy here

Nutrazeutische Therapie

Our Nutraceutical treatment strategy for the detoxification from viral spike protein involves the following 4-step process:

The first step is preventing reinfection by blocking the receptors  on host cells, which the virus and viral spike protein use to gain  entry. 
The second step is to help restore autophagy processes, which are  the body’s natural way of cleaning out damaged cells and regenerating  new ones. 
The third step aids in liberating viruses and viral spike proteins by selectively targeting infected or transfected cells. 
The fourth step facilitates the sequestration of viral spike  protein and virus, effectively removing them. The most efficient way to  do this is H.E.L.P. Apheresis and where that is not possible, the use of  Algerol is indicated.

This  comprehensive approach aims to remove the spike protein from the body  safely while also enhancing the immune system’s ability to prevent  further infections.

At the end of our therapy course we add a 3-6 months NAC Augmented protocol.

Find more about Nutraceutical Therapy here

Medikamentenprotokolle (Antiviral/Antikoagulation und andere)

Medication and supplement protocols increase H.E.L.P. Apheresis results further and can be used to treat patients symptom-specific. The protocols include Antiviral Protocols and Anticoagulation Protocols.

Symptoms the medication protocols focus on are:

– Viral persistence
– Persisting hyper coagulation
– MCAS (mastcell activation syndrome), often combined with gastroparesis
– Endothelial damage, often combined with hypercholesterolaemia 
– Neuro inflammation/brain inflammation
– Fatigue, PEM often combined with mitochondrial dysfunction
– Insomnia 
– Induced anxiety/paranoia/depression 
– Reactivated viruses
– Others

Find more information on Antiviral Therapy and Anticoagulation Therapy

Schmerz- und Angsttherapie

Anxiety, Depression, PTSD, Chronic Pain and Fatigue Therapy for Long Covid and Chronic Illness
Are you or a loved one struggling with the lingering effects of Long Covid or battling the relentless challenges of chronic illness? At the Apheresis Center we understand the toll these conditions can take on both your physical and mental well-being. That’s why we offer revolutionary approaches to treatment.

Find more about Depression & Anxiety Therapy here

Kolon-Hydro-Therapie und MCAS-Behandlung

Colon Hydrotherapy, also known as colonic irrigation, constitutes an internal cleansing procedure designed to rid the colon of deleterious waste materials. This therapeutic intervention serves as a rapid and highly efficient means of detoxification for the body. The mild internal hydration expeditiously eliminates pathogenic toxins by leveraging the natural peristaltic movements, further facilitated by abdominal massage. Notably, this process has implications for individuals with symptoms that present similar to Mast Cell Activation Syndrome (MCAS), as it influence the systemic responses associated with this symptoms often triggered by Long Covid, Post Vac or other Chronic Illnesses.

Our Medical Team has designed a MCAS treatment package which is tailored to each patient individually

MCAS Blood Test (CCL2, IL-6, IL-8, IL-31, IL-33, TNF-alpha, Tryptase)
Nutrition Plan
3x Colon Hydrotherapy, ozonated treatment
3x Leaky Gut IV (L-Lysin, Taurin, L-Alanyl-Glutamin, Glycin, Cholinchlorid, Magnesiumchlorid, Kaliumchlorid 
MCAS Medication Plan including Nutraceuticals and Nanozeolites 

Find more information on Colon Hydrotherapy and MCAS Treatment here

IVIG- und mABs- Therapie

The application of Intravenous Immunoglobulin (IVIG, if subcutaneously administered also called SCIG)) and monoclonal antibodies (mABs) like Evusheld or Xevudy (Sotrovimab) represents a new area in treating Long Covid, Post Vac and Chronic Illnesses. These conditions involve complex immune dysregulation and inflammatory responses. IVIG is a concentrated preparation of immunoglobulins derived from pooled human plasma.
Monoclonal antibodies, designed to target specific components of the immune response, present another avenue for intervention. Both IVIG and mABs are being investigated for their potential to restore immune homeostasis.
The current official indications include symptoms present in chronic illness and many post-viral conditions: Myo- and Pericarditis, Small Fiber Neuropathy but also acute/severe conditions like Sepsis.

Find more about IVIG and mABs Therapy here

Hyperbarer Sauerstoff / Kryotherapie / Ozon-EBOO

For specific symptoms and subgroups after H.E.L.P. Apheresis treatment these treatments can speed up and enforce the recovery process. (Note: HBOT is only administered after H.E.L.P. Apheresis therapy. Ozone-EBOO is only administered after H.E.L.P. Apheresis and only in special cases) 

Find more information on Hyperbaric Oxygen Treatment here and Cryotherapy here

Mitochondriale Therapie

Mitochondrial therapy, also known as metabolic correction, is an emerging approach in the management of Long Covid and chronic illnesses characterized by fatigue. This therapy aims to enhance mitochondrial function, which is often impaired in these conditions, by providing specific nutrients and cofactors that support cellular energy production. Key substances used in mitochondrial therapy include NAC (N-Acetyl L-Cysteine), L-Serine, L-Carnitine, Nicotinamide Riboside (NR), L-Choline, NT Factor, and NADH. These compounds work synergistically to replenish depleted cellular antioxidants, enhance mitochondrial biogenesis, improve fatty acid metabolism, and restore ATP production, ultimately helping to alleviate fatigue and improve overall cellular health in individuals suffering from prolonged symptoms of Long Covid and other chronic fatigue-related conditions.

Find more about Mitochondrial Therapy here

‘Early Treatment Packages’ – Reinfection Care

Many of our last year’s patients had to come back to us for another course of H.E.L.P. Apheresis and Combination Therapy treatment, because they reinfected with Covid and were thrown back to experiencing Long Covid symptoms. This is why we started giving out ‘Early Treatment packages’ which avoid exactly that. Our prescribing doctors will supply you with everything needed to get through your next reinfection without risking to worsen again. 

Beispiel für einen Behandlungsplan

Visualisierung der Behandlungsoptionen des Zypern-Protokolls

In the below PDF you find a visualisation of available treatments (this is solely for the purpose of demonstrating available options – this NOT a real life case/treatment schedule)

Empfehlung: Herunterladen und vergrößern für Details.

PDF herunterladen

Wissenschaftliche Quellen und Studien zur therapeutischen Apherese bei langen Covid/Post Vac und anderen Erkrankungen

H.E.L.P. Apherese

A collection of sources which have published success rates can be found at the Long Covid Apheresis Community (LCA Community): https://lcacommunity.org/research

Die von der LCA Community veröffentlichten Ergebnisse wurden auf der ISFA2023 bestätigt:

ISFA 2023 (Weltkonferenz der Internationalen Gesellschaft für Apherese)

Inuspherese

Science 2024 – new study looking at the relation between microclots and immune damage in Long Covid:

Quote: ‘…coagulation in Long Covid is indicated by the detection of circulating fibrinolysis-resistant microclots that are enriched in vWF, C7, acute-phase serum amyloid proteins, and fibrin, proteins identified in the proteomics screen by Cervia-Hasler et al. as contributors to Long Covid.’

Full study: https://www.science.org/doi/10.1126/science.adn1077

Vereinfacht ausgedrückt, untersucht diese Studie die Gründe für die anhaltenden Symptome bei einigen Menschen nach der Genesung von Covid-19, einer als Long Covid bekannten Erkrankung. Die Forscher fanden heraus, dass bei Long-Covid-Patienten das Immunsystem, insbesondere das Komplementsystem, weiterhin aktiviert ist, was zu Entzündungen und Blutgerinnselbildung führt. Anders als bei der akuten Covid-19-Erkrankung, bei der die Leber eine wichtige Rolle bei der Immunantwort spielt, scheint die Entzündung bei Long Covid eher lokal begrenzt zu sein und Gewebe und Immunzellen zu betreffen. Die Studie deutet darauf hin, dass diese anhaltende Immunaktivierung, insbesondere im Komplementsystem, zu den Symptomen beiträgt, die bei Long-Covid-Patienten auftreten.

Die Forscher identifizierten spezifische Proteine wie Pentraxin 3 und Komplementkomponenten, die mit Long Covid in Verbindung stehen. Das Komplementsystem kann, wenn es unkontrolliert ist, Zellen und Blutgefäße schädigen. Bei Long Covid-Patienten gibt es Hinweise auf eine übermäßige Komplementaktivierung, die zu Entzündungen und zur Bildung von Microclots führt. Dieser anhaltende Entzündungszustand, selbst wenn keine weit verbreitete Blutgerinnung vorliegt, kann die anhaltenden Symptome erklären, die bei Long Covid beobachtet werden, wie Fatigue und kognitive Probleme.

Darüber hinaus fand die Studie Ungleichgewichte bei Faktoren, die mit der Blutgerinnung zusammenhängen, was auf einen möglichen Mechanismus für die Thromboinflammation bei Long Covid hindeutet. Während die genauen Gründe für die anhaltende Immunaktivierung und Blutgerinnung bei Long Covid noch nicht vollständig geklärt sind, deutet die Studie darauf hin, dass die gezielte Beeinflussung bestimmter Komponenten des Immun- und Gerinnungssystems ein möglicher Weg zur Behandlung von Long Covid sein könnte. 

H.E.L.P. Apheresis and Inuspheresis®  address most if not all of the above. Microclots, Hypercoagulation, Inflammation, Pathogens to list just a few modes of action of H.E.L.P. Apheresis and Inuspheresis® . The rest can be addressed by other elements of the multimodal Combination Therapy of ‘The Cyprus Protocol’.

You will find extensive information on our blog post about different types of Apheresis and which type is suitable for which purpose HERE

Unser Apheresezentrum und H.E.L.P. Apherese im TV

ITV News, BBC News, France 2 und WDR TV. Auszüge aus Berichten über unser Apheresezentrum und H.E.L.P. Apherese für Post/Long Covid, Post Vac Syndrom und chronische Krankheiten.

Erfahrungsberichte Patienten

Jeremy Smith, Long Covid, Vereinigte Staaten

‘I had 4 Help Apheresis treatments last year in Germany. They brought me back to 80% of my former capacity. 

The Apheresis Center is a totally different experience and I am super happy I chose Cyprus. It is very different from Germany. The doctors, nurses and the whole team are doing everything to bring me back to my full capacity, their knowledge about Long Covid and the individually adapted treatment is great – a real concierge medicine experience! I missed home last year in Germany – here in Cyprus not a single day, we even extended our stay and will come back next year for holidays!’

You can read and watch Jeremy’s full story here: Full Video

Katrina Krulla, Long Covid, Vereinigte Staaten

‘I have had some amazing results with H.E.L.P. Apheresis for my Long Covid – my 6th treatment got me back to feeling 75% to 90% recovered. Larnaca was truly an amazing place for recovery. Also the great community for support that formed with others getting treatment was so wonderful. It was so nice to have a team of people helping you that “got it” and believed you in addition to being with others suffering the same life changing illness.’

Patricia Price, ME/CFS, Großbritannien

Patricia leidet seit 2015 an schwerem MECFS:

‘My Help Apheresis treatment improved my ME by 80%. Help Apheresis took me from being mostly bed bound 23 hours a day – I could not be upright without my heart jumping to 170 beats per minute, even higher if I tried to have a shower – to being able to be upright and be mobile almost every day. It changed my life! I can now manage my own life again. I can go outside again and I was able to gain weight and can now eat three solid meals a day again!

You can watch Patricia’s full story here: Full Video

Landen Williams, Long Covid, US

Landen kämpfte mit Atemnot, Angstzuständen, Brainfog und anderen Symptomen, bevor wir ihn mit H.E.L.P. Apherese behandelten. Mehrere Monate nach der Behandlung ist er nun wieder zu 70 % er selbst, Fatigue und PEM sind die letzten Symptome, die teilweise noch bestehen. Er bekämpft sie mit einer Kombinationstherapie. Das obige Video ist eine kurze Version/Ausschnitt seines Auftritts bei 1819 News (Quelle: 1819news)

Combination Therapy and H.E.L.P. Apheresis do not achieve the same results in the same time frame for different patients. From our clinical experience we have seen similar success rates as presented on the ISFA 2023 (World Conference of the International Society for Apheresis) – 80% success rate with results varying from smaller improvements to being fully curative. The majority of patients saw a significant improvement. Long Covid, Post Vac and CI are umbrella terms with different subsets – no patient presents the exact same symptoms set.

The time frame in which patients see results also vastly differs – from first treatment to several months. 

ARTE TV-Dokumentation 'Long Covid - Heilung auf Zypern'

ARTE TV-Dokumentation 'Long Covid - Healing in Cyprus' über unser Apheresezentrum

Der Dokumentarfilm wurde im Juni 2024 ausgestrahlt. Ein Journalistenteam des europäischen Fernsehsenders ARTE TV begleitete drei unserer Patienten mit Long Covid und Post-Vac-Syndrom und interviewte sie und unser Team im Apheresezentrum. Hier können Sie sich einen Ausschnitt des Dokumentarfilms ansehen, der auch für Patienten mit kognitiver Dysfunktion, Hirnnebel und damit verbundener Migräne gut zu sehen ist. Englischer Ton von Dubly.

Seit den Dreharbeiten zu diesem Dokumentarfilm wurden neue wissenschaftliche Erkenntnisse gewonnen; die neuesten veröffentlichten Studien finden Sie hier

Markus hat einen Blogbeitrag veröffentlicht hierveröffentlicht, in dem er die Entwicklungen und Aktualisierungen seit den Dreharbeiten zum Dokumentarfilm beschreibt.

Zum Ansehen hier klicken